ENTPD: A Role in DNA Replication and Cell Signaling Pathways (P34643)

Target Name: Ectonucleoside triphosphate diphosphohydrolase

NCBI ID: P34643

Ectonucleoside triphosphate diphosphohydrolase

Other Name(s): ENTPD

ENTPD: A Role in DNA Replication and Cell Signaling Pathways

Ectonucleoside triphosphate diphosphohydrolase (ENTPD) is an enzyme that plays a crucial role in the process of DNA replication in eukaryotic cells. ENTP is a subtype of ENTPD that is expressed in most eukaryotic cells and is involved in the initiation of DNA replication. The ability of ENTP to accurately repair damaged DNA during replication is crucial for the maintenance of genetic accuracy and the development of a healthy cell. However, ENTP has also been shown to have a role in the regulation of cell signaling pathways, cell adhesion, and the process of apoptosis.

ENTPD is a protein that contains three distinct subdomains: a catalytic domain, a nucleotide-binding domain, and a hypervariable region (HVR). The catalytic domain is the active site of the enzyme where the nucleotide is cleaved and the phosphate group is added to the 5' end of the template strand. The nucleotide-binding domain is responsible for binding the nucleotide to the enzyme and the hypervariable region is a region of genetic variation that can occur in the ENTPD gene.

ENTPD has been shown to play a role in the regulation of cell signaling pathways. ENTP has been shown to be involved in the regulation of several intracellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. ENTP has been shown to play a negative role in the regulation of cell proliferation and has been shown to have a role in the regulation of cell apoptosis.

ENTPD has also been shown to have a role in cell adhesion. ENTP has been shown to be involved in the regulation of cell adhesion by the cadherin protein. cadherin is a transmembrane protein that is involved in cell-cell adhesion and is composed of a cytoplasmic domain and a transmembrane domain. ENTP has been shown to play a role in the regulation of the level of cadherin protein in cells, which is necessary for cell adhesion.

ENTPD has also been shown to have a role in the regulation of apoptosis. ENTP has been shown to be involved in the regulation of apoptosis by the Bcl-2 protein. Bcl-2 is a transmembrane protein that is involved in the regulation of apoptosis and is composed of a cytoplasmic domain and a transmembrane domain. ENTP has been shown to play a role in the regulation of the level of Bcl-2 protein in cells, which is necessary for the regulation of apoptosis.

In conclusion, ENTP is an enzyme that plays a crucial role in the process of DNA replication and has also been shown to have a role in the regulation of cell signaling pathways, cell adhesion, and the process of apoptosis. As a result, ENTP is a potential drug target and could be used as a biomarker for the diagnosis and treatment of various diseases. Further research is needed to fully understand the role of ENTP in the regulation of DNA replication and to explore the potential therapeutic benefits of targeting ENTP.

Protein Name: Ectonucleoside Triphosphate Diphosphohydrolase (nonspecified Subtype)

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